Histamine is a multifunctional biogenic amine with relevant roles in intercellular communication, inflammatory processes and highly prevalent pathologies. Histamine biosynthesis depends on a single decarboxylation step, carried out by a PLP-dependent histidine decarboxylase activity (EC 4.1.1.22), an enzyme that still remains to be fully characterized. Nevertheless, during the last few years, important advances have been made in this field, including the generation and validation of the first three-dimensional model of the enzyme, which allows us to revisit previous results and conclusions. (...) This essay provides a comprehensive review of the current knowledge of the structural and functional characteristics of mammalian histidine decarboxylase. BioEssays 27:57–63, 2005. © 2004 Wiley Periodicals, Inc. (shrink)

Membership in voluntary organizations is associated with individual and social benefits. Due to the negative consequences of the global pandemic on older people, and the governmental challenges posed by population aging, voluntary membership is of great importance to society. To effectively promote volunteering among older people, it is necessary to understand the determinants of voluntary membership. This study analyses the influence of individual values—secular/traditional and survival/self-expression–on voluntary membership among European adults. Specifically, it examines which values orient two age groups, as (...) well as men and women toward a certain type of association. The sample of 31,985 comprises 60% of adults aged 50–64 and 40% aged 65–79; of which 56% are women and 44% men. The empirical estimation considers different levels of data aggregation: individual, national and welfare system, therefore multilevel analysis is used as an analytical strategy. Individual-level variables from the Integrated Values Survey and national-level variables from the World Bank and Eurostat are used. The results indicate that traditional and self-expression values promote membership in voluntary organizations in general more than secular and survival values. However, there are differences according to the type of organization. Furthermore, values are found to moderate the effect of age and gender on voluntary membership. (shrink)

This article states that research in skill acquisitionand executionhas underestimated the relevance of some features of attention. We present and theoretically discuss two essential features of attention that have been systematically overlooked in the research of skill acquisitionandexecution. First, attention alters the appearance of the perceived stimuli in an essential way; and second, attention plays a fundamental role in action, being crucial for solving the so called ’many-many problem’, that is to say, the problem of generating a coherent behavior byselecting (...) between many inputs and many potential outputs. We discuss the importance of these features for skill acquisition in sport. We also suggest empirical ways to assess the precise impact of taking them into consideration and at the same time we propose important implications for training derived from the ideas discussed in the paper. (shrink)

For a standard Finsler F on a manifold M, the domain is the whole tangent bundle T M and the fundamental tensor g is positive-definite. However, in many cases, these two conditions hold in a relaxed form only, namely one has either a psuedo-Finsler metric or a conic Finsler metric. Our aim is twofold. First, we want to give an account of quite a few subtleties that appear under such generalizations, say, for conic pseudo-finsler metrics. Second, we aim to provide (...) some criteria that determine when a pseudo-Finsler metric F obtained as a general homogeneous combination of Finsler metrics and one-forms is again a Finsler-metric -- or, more precisely, that the conic domain on which g remains positive-definite. Such a combination generalizes the known -metrics in different directions. Remarkably, classical examples of Finsler metrics are reobtained and extended, with explicit computations of their fundamental tensors. (shrink)

El objetivo de este artículo es ofrecer una perspectiva histórico-filosófica del idealismo y el Romanticismo. La estrategia que emplearemos en esta investigación consiste en analizar dichas corrientes intelectuales a partir del problema, propio de la Modernidad filosófica, de incorporar la libertad dentro de la estructura de la subjetividad humana. El idealismo y el Romanticismo surgieron gracias a la influencia que ejerció el espíritu libre de la Revolución francesa. El espacio donde se desarrolló esta revolución cultural alemana fue el Círculode Jena, (...) un grupo que concentró a muchos de los intelectuales más influyentes en la historia de la filosofía y la literatura. Y fueron las ideas de Immanuel Kant —en específico, con los temas referentes a la apercepción (Yo pienso), la libertad y el genio— la influencia más determinante para los idealistas y losrománticos. (shrink)

Los centros penitenciarios poseen módulos educativos donde se procura dotar de enseñanza reglada a los internos para favorecer su reinserción, como se recoge en la Constitución Española de 1978 así como en los decretos de Enseñanza Secundaria para personas adultas. En este marco, se ofrece aquí una propuesta educativa para desarrollar un tema controvertido, como es el del Holocausto, en un ámbito educativo especialmente sensible a procesos educativos en situaciones de confinamiento, un aula de 4º de ESPA en un centro (...) penitenciario, a través del conocimiento de las responsabilidades criminales consideradas en los Juicios de Núremberg. Utilizando la representación dramática como recurso didáctico, ya que los internos tendrían que reproducir los distintos roles de los participantes en los juicios, se pretende, en las diferentes sesiones en las que está estructurada esta propuesta, tratar de las responsabilidades morales, entender la necesaria existencia de unas instituciones fuertes con códigos de convivencia adecuados y desarrollar la empatía con las víctimas del régimen nazi, con el objetivo de que sean desarrollados valores cívicos entre los internos. (shrink)

Hace tan solo unos ciento sesenta años que la denominada cultura olmeca salió a la luz. En la historia de la definición de su estilo artístico ocupa un lugar destacado el artista mexicano Miguel Covarrubias. En el artículo realizamos un análisis pormenorizado de su obra, intentando mostrar la evolución de sus ideas artísticas y la importancia que tuvieron a la hora de configurar lo que hoy se denomina «estética olmeca». Se analizan sus presupuestos teóricos y la enorme influencia que (...) sus tesis tienen, aun hoy, a la hora de analizar la que muchos consideran la «cultura madre» de Mesoamérica. (shrink)

The aim of this study is to try to make use of real numbers for representing an infinite analysis of individual notions in an infinity of possible worlds.As an introduction to the subject, the author shows, firstly, the possibility of representing Boole's lattice of universal notions by an associate Boole's lattice of rational numbers.But, in opposition to the universal notions, definable by a finite number of predicates, an individual notion, cannot admits this sort of definition, because each state of an (...) individual subject is characterized by the values taken by an infinite number of predicates, each of whom may appear or disappear in the next state.The notion of “degree of identification of an individual notion” is then introduced and arithmetized by a rational number.As an individual notion can be defined by a convergent succession of degrees of identification, the real characteristic number of such an individual notion can be defined by the corresponding convergent succession of rational numbers, satisfying Cauchy's conditions for the convergence of successions. (shrink)

This article evaluates the potential role of advance directives outside of their original North American context. In order to do this, the article first analyses the historical process which has promoted advance directives in recent years. Next, it brings to light certain presuppositions which have given them force: atomistic individualism, contractualism, consumerism and entrepreneurialism, pluralism, proceduralism, and American moralism. The article next studies certain European cultural peculiarities which could affect advance directives: the importance of virtue versus rights, stoicism versus consumerist (...) utilitarianism, rationalism versus empiricism, statism versus citizens' initiative, and justice versus autonomy.The article concludes by recognising that autonomy has a transcultural value, although it must be balanced with other principles. Advance Directives can have a function in certain cases. But it does not seem adequate to delegate to advance directives more and more medical decisions, and to make them more binding everyday. It is indispensable to develop other decision-making criteria. (shrink)

In the parts I and II of this paper, the Author shows:1. how Leibniz’s arithmetico-intensional logical calculi of April 1679 can be completed and transformed in an intensional Boolean algebra (U, v, &:, -, e, -e) admitting, on the one hand, two different logical interpretations:li1: as a complete and consistent calculus of terms (properties) and syllogistic;li2: as a deontic first-order calculus and, on the other hand, two different arithmetical interpretations:ai1: as a numerical Boolean algebra (DM, lcm, ged, M/..., 1, M) (...) of all divisors of a natural number M;ai2: as a numerlcal Boolean algebra (BA, lcbc, gcbc, A-..., 0, A) of all binary components of a natural number A.Arithmetical representations of negation of a term x and of combination (intensional conjunction) and alternative (intensional disjunction) of two or more terms are respectively M/x, lcm (lower common multiple) and gcd (greatest common divisor) in the first Boolean algebra (ai1) and A-x, lcbc (lower common binary composite) and gcbc (greatest common binary component) in the second one (ai2).2. that, in this context, each possible world U of 2ⁿ elements (terms, acts) can be defined on the basis on n elements of U choosen as “saturated” (intensionally maximal, but possible) in U or, inversely, on the basis of n elements of U choosen as “primitive” (intensionally minimal, but not-universal) in U. In fact, each possible element of U can be defined now as an alternative of saturated elements of U, now as a combination of primitive (opposite to saturated) elements of U; all combinations of saturated elements of U being equivalent to the impossible element (-e, non-entity, resp. impossible act) of U and an alternatives of elements of U being equivalent to the universal element (e, entity, resp. possible act) of U.In the arithmetical representation of each possible world U, the maximal number M (for ai1) or A (for ai2) represents the impossible (non existent) element of U. Now, each possihle world defined by n saturated (resp. primitive) elements can be automatically enlarged (restricted) by the introduction (suppression) of m new (old) saturated (resp. primitive) elements, producing a new possible world U’ where m impossible elements (centaur, pegasus, syren, unicorn, etc.) of U become possible elements of U’ or inversely.After this first type of arithmetical representation of logical calculi, where the terms are -as in Leibniz’s 1679 calculi- represented by natural numbers and the propositions by equations (for universal resp. prescriptive) or inequations (for particular, resp. permissive), in the part III the Author presents a second type of arithmetical representation where propositions are represented by natural numbers and the valid (classical or deontic) syllogisms by true arithmetical relations between the numbers of premisses and the number of conclusion. Here the entire syllogistic adopts the form of a multiplication table wherea syllogism is valid if and only if the lcm (in ai1 ) or the lcbc (in ai2) of the characterlstic numbers of the premisses is a multiple (in ai1) or a binary composite (in ai2) of the characteristic number of the conclusion. (shrink)

A través de los recursos esenciales de la semantica de los mundos posibles se comparan y relacionan, por un lado, la dimensión científica y filosófica, y por otro, la dimensión tecnica y la utópica, utilizándose para ello las relaciones entre composibilidad (o compatibilidad) y existencia, y entre el mundo actual, en el que opera la técnica, y mundos posibles, hacia los que se proyecta la utopía. En esta tarea resulta de interés prestar atención a la problematica clasica acerca de los (...) poliedros posibles e imposibles, en relación con el problema de la afectación, exclusión o ajuste de los “monstruos” de la lógica o de la razón.Through the essential means of the semantics of possible worlds, some dimensions are compared and related: firstly, the scientific and philosophical dimension, and secondly the technical and utopian dimension. For that purpose the relationship between compossibility (or compatibility) and existence are used as well as that between the real world, in which technique works, and possible worlds, towards utopia is oriented. In this task it is interesting to pay attention to the classic issue of possible and impossible polyhedrons, concerning affectation, exclusion or fitting of “monsters” of logic or of reason. (shrink)

Descrizione degli obbiettivi, le tecniche ed i primi risultati di una ricerca attualmente in corso all’Università del Paese Basco per applicare il metodo degli invarianti numerici delle classi di equivalenza -già applicato (si veda “Il programma Ars Judicandi”) sul piano di una legislazione nazionale- alla costruzione di un modello matematico per automatizzare le operazioni di analisi logica parallela, confronto e decisione su diverse legislazioni nazionaIi, simultaneamente iscritte nel quadro di una “rete deontica internazionale” che descrive per ciascuna di esse i (...) rapporti validi fra le condizioni, i casi e le soluzioni giuridiche. Il modelle comprende: a) la traduzione in un Iinguaggio aritmetico di base esadecimale delle componenti, le operazioni e le relazioni di una base multinazionale di dati legislativi; b) la formulazione, sotto forma di algoritmi aritmetici, delle regole di utilizzazione della base di dati per gli obbiettivi, classici ed attuali, di analisi e di decisione deI Diritto Comparato e dell’armonizzazione ed integrazione sopranazionale di legisIazioni diverse. (shrink)

An arithmetical language, whose words are natural numbers written in hexadecimal numeration system, is defined and its applications for the representation, analysis and decision of formulae of some logical and normative systems are described and illustrated.The formulae, operations and relations of the represented system are associated as follows respectively to the numbers and the arithmetical operations and relations of the proposed language:1. Each well-formed-formula of the system is associated to a number of a set of natural numbers between zero (associated (...) to all tautologies and theses) and the binary supremum Φ of the set (Φ is associated to all contradictions and antitheses and his value is 2n-1, n depending on system’s dimensions and structure).2. Negation of a formula and disjonction and conjonction of t wo other more formulae of the system are associated respectively to the binary complement Φ-N(f) of the number associated to the first and to the binary infimun and supremum of the numbers associated to the last.3. The logical relations “f1 implies f2” (f1 -> f2), “f1 is incompat.ible with f2” (f1|f2), “f1 is the contradictory opposite of f2” (f1wf2) and “f1 is alternative to f2” (f1vf2) are true in the represented system if and only if the associated arithmetical relations, respectively “N(f1) absorbs arithmetically N(f2)”, “binary supremum of N(f1) and N(f2) is equal to Φ”, “sum of of N(f1) and N(f2) is equal to Φ” and “binary infimum of N(f1) and N(f2) is equal to 0”, are true.The applications of the proposed arithmetical language as very rapid and simplified tool of analysis and decision method are shown for the following systems: propositional logic, syllogistic, some deontic and alethic modal systems and some normative systems of statutory law:1. In the propositional logic, after fixing the maximum of variables considered, the numbers associated to these variables and to the contradictions are calculated. On this permanent basis, the evaluation of a farmula (especially in the case of many occurrences of many variables) is performed by the calculation of the associated number faster as in the traditional way.2. In the syllogistic, after the calculation of the number associated to each type of premise or conclusion, an arithmetical table of syllogisms shows that a proposed syllogism is valid if and only if the binary supremum of the numbers associated to the premises absorbs arithmetically the number associated to the conclusion. It is well-known that the search of this sort of arithmetization of syllogistic and the study of its possibilitiy has been a recurrent topic in modern logic, from Leibniz to Łukasiewicz and to-day.3. In a deontic equivalent:ial system who includes Von Wright’s deontic system of 1982 far norms of the first order, the calculation of the numbers associated to an types of permission and obligation sentences allows the im mediate arithmetical verification of an the classical relations between those sentences. The same is shown for an alethic modal system including the modlities of the first order of Lewis’s S5.4. For normative systems of statutory law, the arithmetical verification of the logical and normative relations is shown in precedent author’s papers -especially in recent “The ‘Ars Judicandi.’ Programme”-, though not yet in hexadecimal numeration system but only in binary and decimal ones.In all the represented systems, the arithmetical verification of the metalogical properties of the system -consistency and completeness- is performed in a very easy and rapid manner, after the arithmetic representation of the axiomatic basis of the latter by a system of equations. (shrink)

Il s’agit d’une methode qui permet d’associer à chaque formule bien formée du système S5 de logique modale un nombre naturel invariant pour toutes les formules qui appartiennent a la même classe d’equivalence que la première.En particulier, étant donné que la méthode associe à toutes les tautologies du système le nombre o et a toutes les contradictions du système un certain nombre Φ, il suffit de calculer le nombre qui, en vertu des associations fondamentales, reste associé à n’importe quelle formule (...) pour décider si cette dernière est tautologique, contradictoire ou contingente.Les relations logiques reliant deux formules du systeme -par exemple, des implications, des incompatibilités, des oppositions contradictaires, etc.- sont révéciés par un simpIe examen oculaire des nombres assoc iés aux formules données et une rapide vérification manuelle ou informatique fondée sur la comparaison des chiffres du même rang de ces nombres, écrits en hexadécimal.Finalement, l’analyse de la composition binaire du nombre associé a une formule donnée permet d’obtenir l’expression de la première sous sa forme normale conjonctive.La méthode décrite constitue donc une nouvelle méthode arithmétique de décision pour le système modal indiqué. (shrink)

En el presente artículo se trata un problema filosófico clásico : el camino epistémico entre la percepción y la formación de conceptos. Se propone una posición doctrinal que afirma que la cognición comienza sin lenguaje pero que gracias a él se asciende hasta la inteligencia humana. Se incluye una referencia a dos momentos de la historia de la gnoseología: la tradición aristotélica enriquecida por la filosofía andalusí y el debate filosófico sobre el tema dentro del empirismo inglés del siglo XVII.

BackgroundMonitoring recovery–stress balance in sport is becoming more relevant to prevent training maladaptation and reach the optimal performance for each athlete. The use of questionnaires that identify the athlete’s recovery–stress state have much acceptance in sports due to reliability and useful, furthermore for its low cost. Identifying possible differences between sport modalities and sex is important to determine specific needs and possible intervention ways to keep a recovery–stress balance. The aim was to analyze the differences in the recovery–stress state and (...) mood states by sex and sport type during the competitive phase in young Mexican athletes. As a secondary objective, the psychometric properties of the Mexican version of the Recovery–Stress Questionnaire for Athletes were analyzed.MethodsA cross-sectional study was carried on with 461 athletes, 17.95 years old, from six sports disciplines. The RESTQ-Sport and Profile of Mood States were applied in a single moment. Differences by sex and sports modality were analyzed. RESTQ-Sport’s confirmatory factor analysis was performed after the stress and recovery theoretical structure of two stress and two recovery dimensions, and last, the concurrent validation with the POMS was carried on.ResultsSignificant differences by sex were found in the General Recovery and Sport Stress dimensions of the RESTQ-Sport as well as Vigor factor of the POMS, being higher for men; furthermore, both the Sport Recovery dimension of RESTQ-Sport and Cholera and the Fatigue and Depression factors from POMS also had differences by sport type, showing a less recovery and high stress for individual sport athletes. Goodness-of-fit indexes of the model for the RESTQ-Sport were acceptable. Pearson’s correlation between questionnaires was moderate.ConclusionThe recovery–stress state shows differences in the function of sex and sport modality. More special attention is suggested for women and individual sport athletes. The higher punctuation for men compared with women in sport stress dimension did not negatively affect the recovery–stress balance for male athletes. Finally, the Mexican context adaptation of the RESTQ-Sport provides a psychometric instrument suitable to assess the recovery–stress balance in Mexican athletes. (shrink)

This paper analyses the arguments for and against what we have called automatic organ procurement model in relation to the organs of the deceased. For this purpose, this work provides empirical evidence to assess the potential impact of this model on donation rates and on public opinion. Specifically, we examine first the reasons supporting this model, with special reference to utilitarian and justice arguments. On the other hand, we analyse both the approaches based on the violation of pre mortem and (...) post mortem interests opposing this theoretical model and the rejection the model would generate in the population. Finally, we point out the aspects that, in our opinion, should be exhaustively regulated if this model were implemented. In particular, we refer to the legal status of the human body, the treatments for end-of-life patients, the incentives for health professionals and the recognition of the right to conscientious objection. (shrink)

Mediante una investigación teórica y de trabajo de campo en relación a la adaptación de la titulación de arquitectura al EEES y con el objetivo de hacer efectivo un despliegue gradual del desarrollo de las competencias del submódulo de dibujo, se exponen los resultados de la coordinación entre asignaturas y una selección crítica y comparativa de actividades de aprendizaje. Se indaga además en la dispar distribución de las materias de dibujo de la adaptación al plan de bolonia, concluyendo con una (...) propuesta de despliegue independiente y mejorada del submódulo desvinculado de las materias que no le son afines. (shrink)

In a previous essay we demonstrated that quantum mechanical formalism is incompatible with some necessary principles of the mechanism conception still dominant in the physicist’s community. In this paper we show, based on recent empirical evidence in quantum physics, the inevitability of abandoning the old mechanism conception and to construct a new one in which physical reality is seen as a representation which refers to relations established through operations made by us in a world that we are determining. This change (...) is profound and radical, with immediate consequences on both Ontology and Epistemology. This work is our contribution to try to make more concrete how this new conception of the world might be. (shrink)

In this work, the evolution of demographic and health patterns in a Basque rural population from Spain is analysed, as they relate to progress in demographic and epidemiological transition. For this purpose, parochial record data on 13,298 births and 9215 deaths, registered during the 19th and 20th centuries (180090) resulting from cardiovascular diseases and malignant neoplasms (post-transition causes). This last point is in contrast with observations from the first four decades of the 20th century, when infectious diseases and respiratory ailments (...) were determining factors in mortality among this population. The data provided by the study of the variation over time in demographic and health patterns indicate that reducing the risk of mortality is one of the most important preconditions for fertility decline. (shrink)

The focus of this work is the analysis of changes in completed family size and possible determinants of that size over time, in an attempt to characterize the evolution of reproductive patterns during the demographic transition. With this purpose in mind, time trends are studied in relation to the mean number of live births per family (as an indirect measure of fertility), using family reconstitution techniques to trace the reproductive history of each married woman. The population surveyed is a Spanish (...) rural community called Lanciego, located at the southern end of the province of Alava (Basque Country). A total of 24,510 parish records of baptisms, marriages and burials made between 1800 and 1969 were examined to obtain the demographic data set. For each reconstituted family, the variables included in the study were the number of live births per family or family size (FAMS), year of marriage (YEAR), age at marriage of both partners (AMAN, AWOM), wife’s age at the end of marriage (WEND), duration of marriage (MARD), age at first maternity (A1CH), length of reproductive span (REPS) and number of children dying before their first anniversary (MINF). Through a principal component analysis, three factors were found that explained more than 75% of the total variance. Association of variables in factors I and III was particularly useful in characterizing the variability of mean family size in pre-transitional, transitional and post-transitional cohorts. During demographic transition, a decreasing trend is observed in the variables FAMS, REPS and MINF, while variables AWOM, AMAN, WEND and A1CH show a tendency to increase over the 20th century. Results obtained by multiple regression analysis confirm that the best predictors of family size (dependent variable) were REPS and MINF, which between them explained over 85% of the total variation in FAMS (R2=0·853). In Lanciego, birth control seems to be present on the evidence of an increase in age at first maternity and a decrease in age at last parturition, indicating that the beginning of the reproductive span is delayed and its end is brought forward. Interaction between family size and infant mortality is discussed in the light of various hypotheses, including replacement of descendants, the so-called biological effect and the theory of r and k selection. (shrink)

La gamificación o ludificación, entendida como la aplicación de la filosofía del juego en contextos no lúdicos, está experimentando en los últimos años un desarrollo espectacular en áreas de diversa naturaleza. Si bien está más que comúnmente aceptado que las funciones principales de los museos consisten en preservar y dar a conocer sus colecciones, resulta fundamental que logren conectar de manera satisfactoria con los usuarios empleando para ello medios y estrategias innovadoras y accesibles. En las siguientes páginas ponemos de manifiesto (...) cómo la gamificación no es sino un recurso idóneo para motivar, fidelizar e influir en el comportamiento de los usuarios. (shrink)

It could be a part of the task of analyzing the history of the World the analysis of the history of rock. Such analysis could take us into a journey and an experience of unexpected paths of wealth and intricate course. Who follows such paths surely will face much more than mere lyrics, costumes, instruments, chords and musical rhythms. That wanderer better be prepared to confront memories and denounces of war, energetic crisis, works of art and a manifold of manifestations (...) of social and political consciousness. Who travel these paths will live fully the experience if submerges him in an alternative and very promising way of meeting the universal history of the last fifty years. This way of understanding history is all about assuming rock as a soundtrack of the multiple features that is the world. In a few words, rock is a key of interpretation of history. (shrink)